Antibody-Binding Proteins and Conjugates
Cayman Chemical PamIdronatesodIum salt 50mg
An alkaloid that has been described as an inhibitor of phosphodiesterase 4 and negative allosteric modulator of L-type Ca2 channels
Cayman Chemical FosphenytoInsodIum salt 500mg
An AChE inhibitor (IC50 24 nM) that prevents amyloid-B production by diminishing the expression of APP
Cayman Chemical RIzatrIptnbenzoate salt 50mg
A sugar sulfamate with anticonvulsant activity inhibits carbonic anhydrase from intact human erythrocytes (Ki ~200 M) as well as blocks sodium and calcium channels and kainite-induced currents in vitro increases GABAA receptor-mediated chloride ion flux inhibits hind-limb tonic-extensor seizures in the maximal electroshock seizure test in mice (ED50 39 mg/kg p.o.)
Cayman Chemical RabeprazolesodIum salt 50mg
A synthetic intermediate useful for pharmaceutical synthesis
Cayman Chemical CefazolInsodIum salt 500mg
A potent inhibitor of IKB kinases (IKKs) displaying IC50 values of 200 40 and 70 nM for IKKa IKKB and IKK complex respectively in cell-free assays effective in cells and in animals
Cayman Chemical 3-SIalylactosesodIum salt 50mg
A diarylpyrimidine derivative of the potent NNRTI efavirenz inhibits HIV-1 reverse transcriptase (IC50 24 nM impedes the late stages of HIV-1 infection by interfering with HIV-1 Gag-Pol polyprotein processing
Cayman Chemical D-LucIferInsodIum salt 500mg
An antibacterial and coccidiostat compound that shows selective toxicity for HMLER breast cancer stem cells (IC50 ~24 M) 8 M treatment of 4T1 and MCF-7-Ras breast cancer cell lines decreases cancer stem cell growth ~2-fold and ~3-fold respectively 5 mg/kg inhibits mammary tumor growth and induces increased epithelial differentiation of tumor cells in mice implanted with SUM159 human breast cancer cells
Cayman Chemical RIsedronatesodIum salt 500mg
A selective ligand for the lipid-binding protein NUCB1 blocking binding of the probe arachidonoyl ethanolamide-diazirine with an IC50 value of 3 3 UM
Cayman Chemical -EtomoxIrsodIum salt 50mg
A synthetic intermediate useful for pharmaceutical synthesis
Cayman Chemical ParecoxIbsodIum salt 50mg
An internal standard for the quantification of ivabradine by GC- or LC-MS
Cayman Chemical DLFolInIc ACDcalcIM salt 500mg
A histamine H2 receptor antagonist (Ki 0 6 M) also acts as an inverse agonist inhibiting basal cAMP production in CHO cells expressing recombinant H2 receptors (IC50 1 2 M) inhibits histamine-induced acid secretion from isolated bullfrog gastric mucosa (IC50 16 M) inhibits histamine-induced gastric acid secretion in gastric fistulae and Heidenhain pouches in dogs (ED50 1 88 mol/kg p o ) reduces tumor growth and neovascularization in a CMT93 colon cancer mouse syngeneic model at 20 mg/kg per day
Cayman Chemical GC376sodIum salt 50mg
A tricyclic diterpene inhibits early-stage adipogenesis of 3T3-L1 cells at 25 and 50 UM inhibits proliferation of HL-60 cells in a concentration-dependent manner as well as induces apoptosis and increases the expression of Fas and Fas ligand (FasL) and the activity of caspase-3 and caspase-8 in HL-60 cells increases P-glycoprotein activity reverses multi-drug resistance and restores cytotoxicity of vinblastine paclitaxel and doxorubicin to MES/SA/Dx5 sarcoma cells
Cayman Chemical AHU377calcIum salt 50mg
LTF4 is a cysteinyl-leukotriene produced in vitro but not reported to date in vivo It is formed by the incubation of LTE4 with Y-glutamyl transpeptidase and glutathione LTF4 is a weak agonist in its ability to contract vascular smooth muscle 547 The rank order of potency of the cysteinyl-leukotrienes to contract vascular smooth muscle is LTD4 LTC4 LTE4 LTF4 547548
Abcam Oligonucleotide Conjugation Kit, 1 x 100UG
Abcam's Oligonucleotide Conjugation Kit (ab218260) offers several standout features: - Rapid Conjugation: enables generation of antibody-oligonucleotide conjugates in less than 2 hours. - High Efficiency: achieves high levels of antibody and oligonucleotide recovery, with conjugation efficiency ~ 95-100%. - Versatility: Suitable for conjugating antibodies to single-stranded oligonucleotides (10-120 bases) and double-stranded oligonucleotides (up to 80 bases), providing flexibility for various research needs
The product is subject to the following: Abcam Restricted Use Statement