Antibody-Binding Proteins and Conjugates
Jackson Immuno Research Labs Fluorescein (FITC)-ChromPure Rat IgG whole molecule
Fluorescein (FITC)-ChromPure Rat IgG whole molecule
Jackson Immuno Research Labs Fluorescein (FITC)-ChromPure Mouse IgG Fab fragment
Fluorescein (FITC)-ChromPure Mouse IgG Fab fragment
Cayman Chemical MaduramIcInamonIum salt 50mg
A polyether ionophore antibiotic; selectively binds to monovalent cations over divalent cations; active against Gram-positive bacteria (MICs = 0.9-125 UG/ml); reduces the viability of asexual and gametocyte P. falciparum parasites (EC50s = 1.3 and 14.8 nM, respectively); reduces P. berghei transmission in a mouse model of malaria at 4 and 8 mg/kg; reduces the severity of lesions and completely protects chicks against mortality in a model of E. tenella-induced coccidiosis at 5-10 ppm in the diet
Cayman Chemical DLFolInIc ACDcalcIM salt 500mg
A formylated form of tetrahydrofolic acid, the reduced form of folic acid; used to prevent toxicity following high-dose methotrexate therapy, to enhance the antitumor activity of 5-fluorouracil, and as a folate supplement
Cayman Chemical 1-thIoD-GlucosesodIum sa 500mg
An analog of β-D-glucose in which sulfur replaces the hydroxyl group at the one position, allowing diverse chemical reactions, including click chemistry and polymerization; can be labeled with technetium-99m for analytical and diagnostic procedures
Biotium Tyrosinase(T311), CF488A conjugate, 0.1mg/mL
Recognizes a cluster of proteins between 70-80 kDa, identified as tyrosinase. Occasionally a minor band at 55 kDa is also detected. This MAb shows no cross-reaction with MAGE-1 and tyrosinase-related protein 1, TRP-1/gp75. Tyrosinase is a copper-containing metalloglycoprotein that catalyzes several steps in the melanin pigment biosynthetic pathway; the hydroxylation of tyrosine to L-3,4-dihydroxy-phenylalanine (dopa), and the subsequent oxidation of dopa to dopaquinone. Mutations of the tyrosinase gene occur in various forms of albinism. Tyrosinase is one of the targets for cytotoxic T-cell recognition in melanoma patients. Staining of melanomas with this MAb shows tyrosinase in melanotic as well as amelanotic variants. This MAb is a useful marker for melanocytes and melanomas.Primary antibodies are available purified, or with a selection of fluorescent CF Dyes and other labels. CF Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent d
Biotium Testosterone(4E1G2), CF488A conjugate, 0.1mg/mL
This MAb is highly specific to testosterone. Its affinity constant for testosterone is ~1010 M-1. In competitive binding immunoassay, it reacts with testosterone 100%, 11-beta-hydroxy testosterone 3.3%, 17-alpha-methyl testosterone <0.1%, 5-alpha DHT 0.8%, estradiol <0.1% and progesterone <0.1%. Testosterone, a steroid hormone from the androgen group, is derived from cholesterol. Testosterone is primarily secreted in the testes, but the ovaries and adrenal glands also produce smaller amounts. It is the principal male sex hormone and is responsible for the maturation of sex organs and the development of male secondary sex characteristics. The hormone is also involved in the growth of muscle mass and increases bone density and maturation. It functions by activating the androgen receptor and converting to estradiol and activation of estrogen receptors. Testosterone has been employed therapeutically to treat many conditions including infertility, lack of libido, osteopor
Cayman Chemical PamIdronatesodIum salt 50mg
An FPP synthase inhibitor (IC50s = 0.85 and 0.20 µM in J774 cells and for human recombinant FPP synthase, respectively); inhibits bone resorption in rats when used at doses of 16 µmol/kg per day and impairs long bone growth at ≥40 µmol/kg per day; has anti-hypercalcemic effects in a rat hypercalcemia model; high concentrations induce activation of MMP-2, NF-κB, and caspase-3, leading to cell death
Cayman Chemical FosInoprIlsodIum salt 50mg
A prodrug form of fosinoprilat; inhibits angiotensin I-induced pressor responses in normotensive rats, dogs, and monkeys at 15, 15, and 10 µmol/kg, respectively; reduces fractional shortening and decreases left ventricular size in a porcine model of congestive heart failure at 2.5 mg/kg
Biotium CD282 / TLR2(TLR2/221), CF647 conjugate, 0.1mg/mL
This MAb reacts with human Toll-like receptor 2 (TLR2). It is a member of the Toll-like receptor (TLR) family, which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is expressed most abundantly in peripheral blood leukocytes, and mediates host response to Gram-positive bacteria and yeast via stimulation of NF-kappaB.Primary antibodies are available purified, or with a selection of fluorescent CF Dyes and other labels. CF Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF405S and CF405M are not recommended for detecting low
Cayman Chemical CefoxItInsodIum salt 500mg
A cephalosporin antibiotic; active against numerous Gram-negative bacteria, including strains of P. mirabilis, P. vulgaris, E. coli, S. typhimurium, and S. enteritidis (MICs = 4-32 UG/ml for all); binds to B. subtilis PBP2a, -2b, -3, -4, and -5 (IC50s = 0.72, 0.19, 1.04, 0.14, and 0.19 UG/ml, respectively); increases survival in mice infected with S. aureus, S. pyogenes, or K. pneumoniae (ED50s = 250, 63, and 795 UG/animal, respectively)
Cayman Chemical FlucloxacIlInsodIum salt 500mg
A β-lactam antibiotic; active against clinical isolates of S. aureus (MICs = 0.12-0.25 mg/L); decreases vegetation titers in a rat model of S. aureus-induced aortic valve endocarditis at 42.3 mg/kg every six hours